%From Jose Pinheiro <jcp@rice.research.bell-labs.com>
\documentclass[a4,semhelv,semcolor,portrait,11pt]{seminar}
%May want to add slidesonly after 11pt if using notes
%Bibliography may work with slidesonly if put it inside a slide
\centerslidesfalse
%\usepackage{S}
\usepackage{graphicx}
%\usepackage{pstricks}
%\newpagestyle{intro}%
%{\sl OVERALL TITLE \hfil SHORT TITLE}{\hfil \thepage}
%\pagestyle{intro}
\slideframe{none}
\graphicspath{{figs/}}
% \DeclareGraphicsExtensions{.eps.gz,.eps,.epsi.gz,.epsi,.ps,.ps.gz}
% \DeclareGraphicsRule{*}{eps}{*}{}
% \DeclareGraphicsRule{.epsi.gz}{eps}{.bb}{`zcat #1}
% \DeclareGraphicsRule{.eps.gz}{eps}{.bb}{`zcat #1}
% \DeclareGraphicsRule{.ps.gz}{eps}{.bb}{`zcat #1}
\setkeys{Gin}{width=\textwidth}
%Example: \fig{myfig}{An example of a good fit on worthless data}
%Inserts postscript figure myfig.ps into document, with caption given
%This is for .ps files not generated by transfig
%\fig{label=.ps prefix}{caption}
\newcommand{\fig}[2]{\begin{figure}[htbp] %
\begin{center}
% can also try \centerline{\includegraphics{}} or \centering b4 includeg.
\leavevmode
\includegraphics{#1}
% \includegraphics[width=0.9\textwidth]{#1}
\end{center}
\caption{#2}
\label{#1}
\end{figure}}
\newcommand{\bs}[1]{\begin{slide*}\Ti{#1}}
\newcommand{\es}{\end{slide*}}
\newcommand{\bi}{\begin{itemize}}
\newcommand{\ei}{\end{itemize}}
\newcommand{\be}{\begin{enumerate}}
\newcommand{\ee}{\end{enumerate}}
\newcommand{\bm}[1]{{\boldsymbol {#1}}}
\newcommand{\Ti}[1]{\hfill {\textbf{\large \blue #1}\\}%
\vspace*{-1cm} \rule{\linewidth}{0.2mm}}
\newcommand{\mg}[1]{{\magenta #1}}
\newcommand{\rd}[1]{{\red #1}}
\newcommand{\bu}[1]{{\blue #1}}
\newcommand{\gr}[1]{{\green #1}}
\newcommand{\Cf}[1]{\textsf{#1}}
\newcommand{\splus}{{S-P\sc{lus}} \mbox{}}
\newcommand{\spc}{$\mbox{}$}
\newcommand{\sct}[1]{{\scriptsize #1}}
\newcommand{\sctm}[1]{{\scriptsize $#1$}}
\begin{document}
\vspace*{\stretch{1}}
\noindent\rule{\linewidth}{1mm}
\begin{flushright}
\huge
TITLE\\[2ex]
\Large Frank E Harrell Jr \\
\normalsize
Division of Biostatistics and Epidemiology \\
Department of Health Evaluation Sciences \\
University of Virginia School of Medicine \\
Box 800717 Charlottesville VA 22908 USA \\
{\tt fharrell@virginia.edu} \\
{\tt hesweb1.med.virginia.edu/biostat} \\
\end{flushright}
\rule{\linewidth}{1mm}
\vspace*{\stretch{2}}
\begin{center}
\textsc{MEETING \\ DATE}
\end{center}
\thispagestyle{empty}
%Shortcut for below:
\bs{Outline}
\be
\item ....
\bi
\item ....
\ei
\ee
\es
\begin{slide*}
\Ti{Outline}
\begin{enumerate}
\item \rd{Introduction}
\begin{itemize}
\item motivating examples of \mg{linear} and \mg{non-linear}
mixed-effects models
\item $x^{2} - \sum_{i=1}^{n}\chi^{2}$
\item a sample of \splus commands for \mg{fitting} and
\mg{analyzing} mixed-effects models.
\end{itemize}
\item \rd{Grouped data}
\begin{itemize}
\item \spc \mg{repeated measures}, \mg{longitudinal} data, \mg{growth
curve} data
\item \spc \mg{multiply-nested} data
\item Data structures, \mg{classes}, and \mg{methods} for grouped
data in \splus
\item \spc \mg{Trellis} displays for grouped data
\end{itemize}
\end{enumerate}
\end{slide*}
\begin{slide*}
\Ti{Outline (cont.'d)}
\begin{enumerate}
\item[3.] \rd{Linear mixed-effects models}
\begin{itemize}
\item brief review of linear models
\item linear mixed-effects (\mg{LME}) model
\item \spc \mg{Multilevel} LME models
\item the \mg{lme} function in \splus
\end{itemize}
\item[4.] \rd{Extending the basic LME model}
\begin{itemize}
\item modelling the random effects \mg{covariance} structure
\item variance functions for modelling \mg{heteroscedasticity}
\item correlation structures: \mg{serial}, \mg{spatial}
\item S-PLUS capabilities for extending and customizing the
\mg{lme} function
\item the \mg{gls} function in \splus
\end{itemize}
\end{enumerate}
\end{slide*}
\begin{slide*}
\Ti{Outline (cont.'d)}
\begin{enumerate}
\item[5.] \rd{Nonlinear mixed-effects models}
\begin{itemize}
\item \spc \mg{nonlinear} regression model
\item starting estimates: \mg{self-starting} models
\item nonlinear mixed-effects (\mg{NLME}) models
\item the \mg{nlme} function in \splus
\item extending the basic \mg{NLME} model
\item using \mg{covariates} with \rd{nlme}
\end{itemize}
\end{enumerate}
\end{slide*}
\begin{slide*}
\Ti{Some examples}
{\red Orthodont} -- orthodontic growth data\\[2ex]
Distance (in millimeters) between the pituitary and the
pterygomaxillary fissure measured every two years for 27 children
(16 males, 11 females) from age 8 until age 14. Reported in
\cite{pot64roy}
{\tiny
\begin{verbatim}
distance age Subject Sex
1 26.0 8 M01 Male
2 25.0 10 M01 Male
3 29.0 12 M01 Male
4 31.0 14 M01 Male
5 21.5 8 M02 Male
6 22.5 10 M02 Male
. . .
104 19.5 14 F10 Female
105 24.5 8 F11 Female
106 25.0 10 F11 Female
107 28.0 12 F11 Female
108 28.0 14 F11 Female
\end{verbatim}}
\begin{itemize}
\item balanced data
\item linear growth with time
\fig{Photo_4}{This is a test. This is only a test.}
\item similar patterns across individuals, but with different
intercepts and slopes \cite{har98dev}
\end{itemize}
\end{slide*}
\bs
\small
\bibliographystyle{abbrv}
\bibliography{feh}
\es
\bs{Abstract}
{\small
. . . . .
}
\es
\end{document}
